General Information


DRAVP ID  DRAVPe02146

Peptide Name   Valinomycin; streptodepsipeptides P11A and SV21

Sequence  AVVVDAVVVDAVVVDAVVVD

Sequence Length  20

UniProt ID  None  

Taxon ID  None 

Source  Bacterial symbiont Streptomyces sp. SV21

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  HCV

Assay  Anti-HCV assay

Activity 

  • [Ref:33540548]HCV:IC50=0–5%

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not found

Mechanism  viral surface, due to the presence of hydrophobic amino acid



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C54H90N6O18

Absent amino acids  RNCQEGHHILKMFPSTWYOU

Common amino acids  V

Mass  1952.28

Pl  3.32

Basic residues  0

Acidic residues  4

Hydrophobic residues  10

Net charge  -4

Boman Index  0.96

Hydrophobicity  2.18

Aliphatic Index  194

Half Life 

  •     Mammalian:4.4 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  12



Literature Information


Literature 1

Title   Anti-Infective and Antiviral Activity of Valinomycin and Its Analogues from a Sea Cucumber-Associated Bacterium, Streptomyces sp. SV 21

Pubmed ID   33540548

Reference    Marine drugs, 19(2), 81.

Author   Wibowo, J. T., Kellermann, M. Y., Köck, M., Putra, M. Y., Murniasih, T., Mohr, K. I., Wink, J., Praditya, D. F., Steinmann, E., & Schupp, P. J. (2021). 

DOI   10.3390/md19020081