DRAVP ID  DRAVPe02148

Peptide Name   SARS-CoV-2 HRC

Sequence  DISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGSGSGCTEG

Sequence Length  45

UniProt ID  None  

Taxon ID  None 

Source  C-terminal HR domain of SARS-CoV-2

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  SARS-CoV-2 and MERS-CoV

Assay  cell-cell fusion assay

Activity 

• [Ref:20032190]SARS-CoV:IC50≈3nM and ~6nM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref:20032190]No toxicity was observed for the SARS-CoV-2 lipopeptide at its IC90 concentration

Binding Target  Not found

Mechanism  Not Available

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Chlo

Other Modification  None

Stereochemistry  L

Literature 1

Title   Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae

Pubmed ID   20032190

Reference   Journal of virology, 84(5), 2511–2521.

Author   O'Keefe, B. R., Giomarelli, B., Barnard, D. L., Shenoy, S. R., Chan, P. K., McMahon, J. B., Palmer, K. E., Barnett, B. W., Meyerholz, D. K., Wohlford-Lenane, C. L., & McCray, P. B., Jr (2010)

DOI   10.1128/JVI.02322-09