To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02153
Peptide Name P6
Sequence YQDVNCTDVSTAIHADQLTP
Sequence Length 20
UniProt ID P59594
Taxon ID 694009
Source S1 subunit of SARS-CoV
Validation Experimentally Validated
Origin Information
Gene Name/ID S2
GenBank AAP13441.1
Amino Acid position 598-617
Domain Accession ID Not Available
Nucleotide sequence ID AY274119.3
Molecular Type Genomic RNA
Chromosomal Position Chromosome:21,492 - 25,259
Activity Information
Target Organism SARS-CoV-2
Assay antiviral Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism the SI was higher than 5 considering the CC50 at 400 mg.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C92H143N25O35S1
Absent amino acids RQSWOU
Common amino acids DT
Mass 2191.35
Pl 3.93
Basic residues 0
Acidic residues 3
Hydrophobic residues 14
Net charge -3
Boman Index 0.9576
Hydrophobicity -0.36
Aliphatic Index 78
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 0.68
Polar residues 16
Literature Information
Literature 1
Title Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus
Pubmed ID 15918330
Reference Antiviral therapy, 10(3), 393–403.
Author Zheng, B. J., Guan, Y., Hez, M. L., Sun, H., Du, L., Zheng, Y., Wong, K. L., Chen, H., Chen, Y., Lu, L., Tanner, J. A., Watt, R. M., Niccolai, N., Bernini, A., Spiga, O., Woo, P. C., Kung, H. F., Yuen, K. Y., & Huang, J. D. (2005).
DOI Not Available
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.