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General Information
DRAVP ID DRAVPe02154
Peptide Name SP-10 (residues 668-679)
Sequence STSQKSIVAYTM
Sequence Length 12
UniProt ID P59594
Taxon ID 694009
Source S protein of SARS-CoV
Validation Experimentally Validated
Origin Information
Gene Name/ID S2
GenBank AAP13441.1
Amino Acid position 668-679
Domain Accession ID Not Available
Nucleotide sequence ID AY274119.3
Molecular Type Genomic RNA
Chromosomal Position Chromosome:21,492 - 25,259
Activity Information
Target Organism SARS-CoV
Assay Biotinylated enzyme-linked immunosorbent assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target S protein to ACE2
Mechanism Significantly blocked the interaction between S protein and ACE2 by biotinylated enzyme-linked immunosorbent assay.SP-10 blocked both binding of the S protein and infectivity of S protein-pseudotyped retrovirus to Vero E6 cells.
Structure Information
PDB ID 1WYY, 5WRG, 5X58, 5X5B, 5XLR, 5ZVM, 6ACC, 6ACD
Predicted Structure Download No predicted structure available
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C56H94N14O20S1
Absent amino acids RNDCEGHLFPWOU
Common amino acids S
Mass 1315.5
Pl 8.31
Basic residues 1
Acidic residues 0
Hydrophobic residues 10
Net charge 1
Boman Index 0.96
Hydrophobicity -0.008
Aliphatic Index 65
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 1.113
Polar residues 12
Literature Information
Literature 1
Title Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction
Pubmed ID 16337697
Reference Antiviral research, 69(2), 70–76.
Author Ho, T. Y., Wu, S. L., Chen, J. C., Wei, Y. C., Cheng, S. E., Chang, Y. H., Liu, H. J., & Hsiang, C. Y. (2006).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.