General Information

General Information

DRAVP ID DRAVPe02157

Peptide Name P10

Sequence IQKEIDRLNEVAKNLNESLI

Sequence Length 20

UniProt ID P59594

Taxon ID 694009

Source HR2 region of SARS-CoV

Validation Experimentally Validated

Origin Information

Gene Name/ID S2

GenBank AAP13441.1

Amino Acid position 1161-1180

Domain Accession ID Not Available

Nucleotide sequence ID AY274119.3

Molecular Type Genomic RNA

Chromosomal Position Chromosome:21,492 - 25,259

Activity Information

Target Organism SARS-CoV

Assay antiviral Assay

Activity

[Ref:15918330]SARS-CoV:IC90=73.5±15.7μg/mL

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref: 30646495]No cytotoxicity

Binding Target Not Found

Mechanism Not Available

Structure Information

PDB ID 1WYY, 5WRG, 5X58, 5X5B, 5XLR, 5ZVM, 6ACC, 6ACD

Predicted Structure Download No predicted structure available

Linear/Cyclic Cyclic

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C101H175N29O34

Absent amino acids CGHMFPTWYOU

Common amino acids NIL

Mass 2339.67

Pl 4.87

Basic residues 3

Acidic residues 4

Hydrophobic residues 14

Net charge -1

Boman Index 0.9576

Hydrophobicity -0.51

Aliphatic Index 136.5

Half Life

Mammalian:20 hour
Yeast:30 min
E.coli:>10 hours

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 16

Literature Information

Literature 1

Title Synthetic peptides outside the spike protein heptad repeat regions as potent inhibitors of SARS-associated coronavirus

Pubmed ID 15918330

Reference Antiviral therapy, 10(3), 393–403.

Author Zheng, B. J., Guan, Y., Hez, M. L., Sun, H., Du, L., Zheng, Y., Wong, K. L., Chen, H., Chen, Y., Lu, L., Tanner, J. A., Watt, R. M., Niccolai, N., Bernini, A., Spiga, O., Woo, P. C., Kung, H. F., Yuen, K. Y., & Huang, J. D. (2005).

DOI Not Available