DRAVP ID  DRAVPe02158

Peptide Name   MERS-5HB

Sequence  GGRGGGGSGGSGGSGGRGGGGSGGSGG

Sequence Length  27

UniProt ID  None  

Taxon ID  None 

Source  S2 subunit of MERS-CoV

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  MERS-CoV

Assay  ELISA

Activity 

• [Ref:28906430]MERS-CoV:IC50=The 50% inhibitory concentration (IC50) for the inhibition by MERS-5HB of a MERS-CoV infection was about 1 μM, 

Hemolytic Activity 

• [Ref:28906430]The calculated 50% effective concentration (EC50) of binding of MERS-5HB to MERS-HR2P is 5.4 nM.To confirm the binding, the ELISA assay was performed in the reverse way. MERS-5HB was coa

Cytotoxicity 

• [Ref: 30646495]No cytotoxicity

Binding Target  HR2 

Mechanism   The absence of one HR2 may reserve a hydrophobic groove in MERS-5HB for binding to a native HR2 in the MERS-CoV S protein.It could bind to HR2 in MERS-CoV S2 to inhibit viral entry as well as S protein-mediated syncytial formation.

PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Cyclic

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus

Pubmed ID   28906430

Reference   Viruses. 2017 Sep 14;9(9):255.

Author   Sun Y, Zhang H, Shi J, Zhang Z, Gong R.

DOI   10.3390/v9090255