General Information


DRAVP ID  DRAVPe02174

Peptide Name   K12

Sequence  GGASCCLYCRCH

Sequence Length  12

UniProt ID  P0C6U8 

Taxon ID  694009 

Source  Sequence of nsp 10 of SARS-CoV

Validation   Experimentally Validated



Origin Information


Gene Name/ID  1a

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SARS-CoV

Assay  Not Available

Activity 

  • [Ref:22659295]SARS-CoV,IC50=160μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not Found

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C49H77N17O15S4

Absent amino acids  NDQEIKMFPTWVOU

Common amino acids  C

Mass  1272.5

Pl  7.9

Basic residues  1

Acidic residues  0

Hydrophobic residues  10

Net charge  1

Boman Index  0.633

Hydrophobicity  0.417

Aliphatic Index  40.83

Half Life 

  •     Mammalian:30 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  1490

Absorbance 280nm  1.171

Polar residues  12



Literature Information


Literature 1

Title   Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2'-O-methyltransferase activity of nsp10/nsp16 complex

Pubmed ID   22659295

Reference   Virus research, 167(2), 322–328.

Author   Ke, M., Chen, Y., Wu, A., Sun, Y., Su, C., Wu, H., Jin, X., Tao, J., Wang, Y., Ma, X., Pan, J. A., & Guo, D. (2012).

DOI   10.1016/j.virusres.2012.05.017