General Information


DRAVP ID  DRAVPe02175

Peptide Name   K29

Sequence  FGGASCCLYCRCHIDHPNPKGFCDLKGKY

Sequence Length  29

UniProt ID  P0C6U8 

Taxon ID  694009 

Source  Sequence of nsp 10 of SARS-CoV

Validation   Experimentally Validated



Origin Information


Gene Name/ID  1a

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SARS-CoV

Assay  Not Available

Activity 

  • [Ref:22659295]SARS-CoV,IC50=160μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not Found

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C141H210N40O38S5

Absent amino acids  QEMWVOU

Common amino acids  C

Mass  3233.76

Pl  8.4

Basic residues  4

Acidic residues  2

Hydrophobic residues  18

Net charge  2

Boman Index  0.918

Hydrophobicity  -0.321

Aliphatic Index  43.78

Half Life 

  •     Mammalian:1.1 hours
  •     Yeast:3 min
  •     E.coli:2 min

Extinction Coefficient cystines  2980

Absorbance 280nm  0.922

Polar residues  22



Literature Information


Literature 1

Title   Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2'-O-methyltransferase activity of nsp10/nsp16 complex

Pubmed ID   22659295

Reference   Virus research, 167(2), 322–328.

Author   Ke, M., Chen, Y., Wu, A., Sun, Y., Su, C., Wu, H., Jin, X., Tao, J., Wang, Y., Ma, X., Pan, J. A., & Guo, D. (2012). 

DOI    10.1016/j.virusres.2012.05.017