DRAVP ID  DRAVPe02176

Peptide Name   APB-13

Sequence  ILPWKWPWWPWRR

Sequence Length  13

UniProt ID  P33046  A3KN14  

Taxon ID  9913 

Source  Cattle

Validation   Experimentally Validated

Gene Name/ID  CATHL4

GenBank  CAA47755.1

Amino Acid position  131-143

Domain Accession ID  282166 

Nucleotide sequence ID  CM008189.2 

Molecular Type  mRNA

Chromosomal Position  Primary_assembly 22: 51,592,817-51,594,193 reverse strand.

Target Organism  TGEV

Assay  TCID50 assay.

Activity 

• [Ref:33016025]TGEV,IC50=62.5μg/mL

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• The results showed that the APB-13 concentrations from 0 to 62.5 µg/mL were relatively non-toxic to the cells, and the cell states and mean OD values of the ST cells treated with APB-13 for these conc

Binding Target  N Protein

Mechanism  APB-13 inhibited TGEV replication, and within a certain range, the mRNA and protein expression levels of the N protein increased gradually as the APB-13 concentration decreased.

PDB ID  1G8C  1G89  

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antiviral effects of Bovine antimicrobial peptide against TGEV in vivo and in vitro

Pubmed ID   33016025

Reference   Journal of veterinary science, 21(5), e80.

Author   Liang, X., Zhang, X., Lian, K., Tian, X., Zhang, M., Wang, S., Chen, C., Nie, C., Pan, Y., Han, F., Wei, Z., & Zhang, W. (2020).

DOI   10.4142/jvs.2020.21.e80