General Information


DRAVP ID  DRAVPe02182

Peptide Name   W

Sequence  WSFNPSTYTIAG

Sequence Length  12

UniProt ID  None  

Taxon ID  None 

Source  S1 protein of PEDV

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  PEDV

Assay  Plaque-reduction assay

Activity 

  • [Ref:26292945]PEDV,IC50=50μg/mL

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Cell surface

Mechanism  Two peptides derived from phage display libraries were identified with sequence homology to a specific region of the PEDV S1 protein and that affect binding of the PEDV to the cell surface



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C63H86N14O19

Absent amino acids  RDCQEHKMOU

Common amino acids  ST

Mass  1343.46

Pl  5.52

Basic residues  0

Acidic residues  0

Hydrophobic residues  10

Net charge  0

Boman Index  0.99

Hydrophobicity  -0.133

Aliphatic Index  40.83

Half Life 

  •     Mammalian:2.8 hours
  •     Yeast:3 mins
  •     E.coli:2 min

Extinction Coefficient cystines  6990

Absorbance 280nm  5.203

Polar residues  12



Literature Information


Literature 1

Title   Putative phage-display epitopes of the porcine epidemic diarrhea virus S1 protein and their anti-viral activity

Pubmed ID   26292945

Reference   Virus genes, 51(2), 217–224.

Author   Cao, L., Ge, X., Gao, Y., Zarlenga, D. S., Wang, K., Li, X., Qin, Z., Yin, X., Liu, J., Ren, X., & Li, G. (2015).

DOI    10.1007/s11262-015-1234-5