General Information


DRAVP ID  DRAVPe02183

Peptide Name   TGEV-M7

Sequence  HALTPIKYIPPG

Sequence Length  12

UniProt ID  None  

Taxon ID  None 

Source  M protein of TGEV

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  TGEV

Assay  Plaque-reduction assay

Activity 

  • [Ref:23830854]TGEV,IC50=62.5μg/mL

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  rTGEV-M protein

Mechanism  pepTGEV-M7 binding to the surface of the virus and either interfering with the ability of the virus to invade the cell or generate progeny virus. 



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C63H99N15O15

Absent amino acids  RNDCQEMFSWVOU

Common amino acids  P

Mass  1306.57

Pl  8.06

Basic residues  1

Acidic residues  0

Hydrophobic residues  10

Net charge  1

Boman Index  0.99

Hydrophobicity  0.025

Aliphatic Index  105.83

Half Life 

  •     Mammalian:3.5 hours
  •     Yeast:10 mins
  •     E.coli:>10 hours

Extinction Coefficient cystines  1490

Absorbance 280nm  1.14

Polar residues  12



Literature Information


Literature 1

Title   Transmissible gastroenteritis virus: identification of M protein-binding peptide ligands with antiviral and diagnostic potential

Pubmed ID   23830854

Reference   Antiviral research, 99(3), 383–390.

Author   Zou, H., Zarlenga, D. S., Sestak, K., Suo, S., & Ren, X. (2013).

DOI   10.1016/j.antiviral.2013.06.015