General Information


DRAVP ID  DRAVPe02188

Peptide Name   I-S1-10

Sequence  YTDVMVDVNGTAITRLFYCD

Sequence Length  20

UniProt ID  Q66951 

Taxon ID  11135 

Source  S1 protein of FIPV

Validation   Experimentally Validated



Origin Information


Gene Name/ID  S

GenBank  Not Available

Amino Acid position  481-500

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  FIPV

Assay  Plaque-reduction assay

Activity 

  • [Ref:25896976]FIPV,IC50=~60μg/mL

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not given

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download  No predicted structure available

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C101H154N24O33S2

Absent amino acids  QEHPSWOU

Common amino acids  DTV

Mass  2296.59

Pl  3.93

Basic residues  1

Acidic residues  3

Hydrophobic residues  18

Net charge  -2

Boman Index  0.9185

Hydrophobicity  0.315

Aliphatic Index  87.5

Half Life 

  •     Mammalian:2.8 hours
  •     Yeast:10 min
  •     E.coli:2 min

Extinction Coefficient cystines  2980

Absorbance 280nm  1.298

Polar residues  22



Literature Information


Literature 1

Title   Identification of the peptide derived from S1 domain that inhibits type I and type II feline infectious peritonitis virus infection

Pubmed ID   25896976

Reference   Virus research, 204, 13–20.

Author   Doki, T., Takano, T., Koyama, Y., & Hohdatsu, T. (2015).

DOI   10.1016/j.virusres.2015.04.014