To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02191
Peptide Name Alstotide As3
Sequence CVPRFGRCDGIINOCCDPYLCTPPLVGICT
Sequence Length 30
UniProt ID None
Taxon ID None
Source Alstonia scholaris plant
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism IBV
Assay Antiviral Activity Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target S protein
Mechanism The putative antiviral mechanism of As1 is through its interference with S protein function during IBV entry.
Structure Information
PDB ID None
Predicted Structure Download No predicted structure available
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C146H233N39O40S6
Absent amino acids AEKMFWOU
Common amino acids C
Mass 3367.05
Pl 5.92
Basic residues 2
Acidic residues 2
Hydrophobic residues 24
Net charge 0
Boman Index 0.9576
Hydrophobicity 0.583
Aliphatic Index 84.33
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 0.443
Polar residues 32
Literature Information
Literature 1
Title Antiviral Cystine Knot α-Amylase Inhibitors from Alstonia scholaris
Pubmed ID 26546678
Reference The Journal of biological chemistry, 290(52), 31138–31150.
Author Nguyen, P. Q., Ooi, J. S., Nguyen, N. T., Wang, S., Huang, M., Liu, D. X., & Tam, J. P. (2015).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.