To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02194
Peptide Name eVpeL2
Sequence YFKSVRTGLRYVYCS
Sequence Length 15
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay AlphaLISA assay,
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target VP24
Mechanism eVpeL2 exhibit inhibitory activity against the protein-protein interaction (PPI) of VP24 and KPNA5.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Amidation
C-terminal Modification Acetylation
Other Modification (In the peptide sequence, the N-terminus is acetylated, and the tyrosine residue at position 1 is in the D-configuration.)
Stereochemistry L
Physicochemical Information
Formula C85H128N22O22S1
Absent amino acids ANDQEMPWOU
Common amino acids Y
Mass 1842.15
Pl 9.63
Basic residues 3
Acidic residues 0
Hydrophobic residues 5
Net charge 3
Boman Index 1.79
Hydrophobicity -0.133
Aliphatic Index 64.67
Half Life
Extinction Coefficient cystines 4470
Absorbance 280nm 2.427
Polar residues 6
Literature Information
Literature 1
Title Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5.
Pubmed ID 28574091
Reference Org Biomol Chem. 2017;15(24):5155-5160.
Author Song X, Lu LY, Passioura T, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.