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General Information
DRAVP ID DRAVPe02196
Peptide Name delta1-28-Fc
Sequence ELQREESPTGPPGSIRTWFQRIPLGWFH
Sequence Length 28
UniProt ID P60172, Q7T9E0
Taxon ID 128948
Source eboV delta peptide
Validation Experimentally Validated
Origin Information
Gene Name/ID GP
GenBank AAB37097.2
Amino Acid position 325-352
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay Antiviral Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Glycoprotein.
Mechanism The efficacy of delta-Fc and its truncated versions (delta1-28-Fc, delta1-33-Fc, delta1-39-Fc, delta13-48-Fc, delta28-48-Fc, delta7-48-Fc, delta18-48-Fc, delta1-17-Fc) in inhibiting Ebola virus (EBOV) entry was investigated, demonstrating specific binding to filovirus-permissive cells and inhibition of EBOV glycoprotein GP1,2 entry. These Fc-tagged peptides interfere with the viral entry process, potentially preventing superinfection of producer cells and inhibiting cell transduction with filoviruses. The mechanisms of action involve binding to cell surface receptors or disrupting key viral entry steps.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C153H225N43O41
Absent amino acids ANDCKMYVOU
Common amino acids P
Mass 3322.73
Pl 6.86
Basic residues 3
Acidic residues 3
Hydrophobic residues 8
Net charge 0
Boman Index 2.13
Hydrophobicity -0.871
Aliphatic Index 55.71
Half Life
Extinction Coefficient cystines 11000
Absorbance 280nm 3.31
Polar residues 6
Literature Information
Literature 1
Title Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry
Pubmed ID 21697477
Reference J Virol. 2011;85(17):8502-13.
Author Radoshitzky SR, Warfield KL, Chi X, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.