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General Information
DRAVP ID DRAVPe02200
Peptide Name delta28-48-Fc
Sequence HCTYQKGKQHCRLRIRQKVEE
Sequence Length 21
UniProt ID P60172, Q7T9E0
Taxon ID 128948
Source EboV delta peptide
Validation Experimentally Validated
Origin Information
Gene Name/ID GP
GenBank AAB37097.6
Amino Acid position 352-372
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay Antiviral Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Glycoprotein.
Mechanism The efficacy of delta-Fc and its truncated versions (delta1-28-Fc, delta1-33-Fc, delta1-39-Fc, delta13-48-Fc, delta28-48-Fc, delta7-48-Fc, delta18-48-Fc, delta1-17-Fc) in inhibiting Ebola virus (EBOV) entry was investigated, demonstrating specific binding
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C111H186N40O31S2
Absent amino acids ANDHMFPSWOU
Common amino acids RQK
Mass 2641.07
Pl 9.7
Basic residues 6
Acidic residues 2
Hydrophobic residues 5
Net charge 4
Boman Index 4.1
Hydrophobicity -1.619
Aliphatic Index 50.95
Half Life
Extinction Coefficient cystines 12490
Absorbance 280nm 0.564
Polar residues 5
Literature Information
Literature 1
Title Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry
Pubmed ID 21697477
Reference J Virol. 2011;85(17):8502-13.
Author Radoshitzky SR, Warfield KL, Chi X, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.