To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02201
Peptide Name delta7-48-Fc
Sequence SPTGPPGSIRTWFQRIPLGWFHCTYQKGKQHCRLRIRQKVEE
Sequence Length 42
UniProt ID P60172, Q7T9E0
Taxon ID 128948
Source EboV delta peptide
Validation Experimentally Validated
Origin Information
Gene Name/ID GP
GenBank AAB37097.7
Amino Acid position 331-372
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay Antiviral Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Glycoprotein.
Mechanism The efficacy of delta-Fc and its truncated versions (delta1-28-Fc, delta1-33-Fc, delta1-39-Fc, delta13-48-Fc, delta28-48-Fc, delta7-48-Fc, delta18-48-Fc, delta1-17-Fc) in inhibiting Ebola virus (EBOV) entry was investigated, demonstrating specific binding
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C226H350N70O57S2
Absent amino acids ANDMOU
Common amino acids R
Mass 5023.82
Pl 10.44
Basic residues 8
Acidic residues 2
Hydrophobic residues 12
Net charge 6
Boman Index 2.5
Hydrophobicity -0.964
Aliphatic Index 53.33
Half Life
Extinction Coefficient cystines 12490
Absorbance 280nm 2.486
Polar residues 10
Literature Information
Literature 1
Title Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry
Pubmed ID 21697477
Reference J Virol. 2011;85(17):8502-13.
Author Radoshitzky SR, Warfield KL, Chi X, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.