To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02204
Peptide Name Peptidyl chloromethylketone
Sequence RVKRCMK
Sequence Length 7
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay Endoproteolytic Cleavage Inhibition Assay. ≥90% (HPLC)
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Glycoprotein.
Mechanism Peptidyl chloromethylketones, exemplified by decRVKR-cmk, function as potent inhibitors of the endoproteolytic cleavage of the Ebola virus glycoprotein. They operate by obstructing the cleavage of the glycoprotein specifically at a multibasic amino acid motif situated between positions 497 and 501 of the ORF. This cleavage is essential for the glycoprotein's maturation into its functional state. By impeding this cleavage process, peptidyl chloromethylketones hinder the glycoprotein's transformation into its mature form, thereby disrupting the viral replication cycle and potentially diminishing the virus's infectivity.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C37H73N15O8S2
Absent amino acids ANDQEGHILFPSTWYOU
Common amino acids RK
Mass 920.2
Pl 11.01
Basic residues 4
Acidic residues 0
Hydrophobic residues 3
Net charge 4
Boman Index 4.75
Hydrophobicity -1.171
Aliphatic Index 41.43
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Literature Information
Literature 1
Title Processing of the Ebola virus glycoprotein by the proprotein convertase furin
Pubmed ID 9576958
Reference Proc Natl Acad Sci U S A. 1998;95(10):5762-7.
Author Volchkov VE, Feldmann H, Volchkova VA, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.