To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02205
Peptide Name PMO
Sequence RRRRRRRRRFFC
Sequence Length 13
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV,EBOV
Assay Antiviral Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target VP35
Mechanism PMOs, a type of single-stranded antisense agents, exert their antiviral action against Ebola virus by binding to specific RNA sequences, particularly within the VP35 translation start site region, thereby impeding viral replication. Their mechanism involves blocking the translation of essential viral proteins, like VP35, crucial for Ebola's replication, leading to a sequence-specific and dose-dependent inhibition of viral amplification both in vitro and in vivo. This inhibition ultimately safeguards against lethal Ebola infection in mice, showcasing PMOs' efficacy in curtailing viral spread.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Amination
C-terminal Modification Free
Other Modification (In the peptide sequence, N-terminus is modified with an amino group (NH2).)
Stereochemistry L
Physicochemical Information
Formula C75H133N39O13S1
Absent amino acids ANDQEGHILKMPSTWYVOU
Common amino acids R
Mass 1821.19
Pl 12.54
Basic residues 9
Acidic residues 0
Hydrophobic residues 3
Net charge 9
Boman Index 10.58
Hydrophobicity -2.7
Aliphatic Index 0
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Literature Information
Literature 1
Title VP35 knockdown inhibits Ebola virus amplification and protects against lethal infection in mice.
Pubmed ID 16495261
Reference Antimicrob Agents Chemother. 2006;50(3):984-93.
Author Enterlein S, Warfield KL, Swenson DL, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.