To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02206
Peptide Name P1
Sequence LYDRLASTVI
Sequence Length 10
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 161 to 169
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay PRNT50 assays
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Other (immunogenic epitope).
Mechanism Peptide P1 likely works against the Ebola virus by serving as an immunogenic epitope, stimulating the activation and proliferation of cytotoxic T lymphocytes (CTLs) specific to the Ebola virus glycoprotein (GP). This activation of CTLs enables them to recognize and eliminate virus-infected cells, contributing to the immune response against Ebola virus infection.
Structure Information
PDB ID 3CSY, 3S88, 3VE0, 5F1B, 5FHC, 5HJ3, 5JQ3, 5JQ7, 5K
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C52H87N13O16
Absent amino acids NCQEGHKMFPWOU
Common amino acids L
Mass 1150.34
Pl 5.84
Basic residues 1
Acidic residues 1
Hydrophobic residues 5
Net charge 0
Boman Index 0.91
Hydrophobicity 0.73
Aliphatic Index 156
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 1.295
Polar residues 3
Literature Information
Literature 1
Title Induction of immune responses in mice and monkeys to Ebola virus after immunization with liposome-encapsulated irradiated Ebola virus: protection in mice requires CD4(+) T cells.
Pubmed ID 12186901
Reference J Virol. 2002;76(18):9176-85.
Author Rao M, Bray M, Alving CR, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.