To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02207
Peptide Name P2
Sequence EYLFEVDNL
Sequence Length 9
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position 231 to 239
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay PRNT50 assays
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Other (immunogenic epitope).
Mechanism Peptide P2 acts against Ebola virus by stimulating cytotoxic T lymphocytes (CTLs) specific to the Ebola virus glycoprotein (GP). When used in immunization alongside liposome-encapsulated irradiated Ebola virus, P2 contributes to the generation of a CTL response aimed at targeting and eliminating virus-infected cells. This specificity was demonstrated by the enhanced lysis of target cells infected with vaccinia virus GP when effector cells from mice immunized with liposome-encapsulated virus were cultured with peptide P2, suggesting its role in inducing a more precise immune response against Ebola virus GP.
Structure Information
PDB ID 3CSY, 3S88, 3VE0, 5F1B, 5FHC, 5HJ3, 5JQ3, 5JQ7, 5K
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C53H76N10O18
Absent amino acids ARCQGHIKMPSTWOU
Common amino acids EL
Mass 1141.24
Pl 3.57
Basic residues 0
Acidic residues 3
Hydrophobic residues 4
Net charge -3
Boman Index 1.36
Hydrophobicity -0.078
Aliphatic Index 118.89
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 1.306
Polar residues 2
Literature Information
Literature 1
Title Induction of immune responses in mice and monkeys to Ebola virus after immunization with liposome-encapsulated irradiated Ebola virus: protection in mice requires CD4(+) T cells.
Pubmed ID 12186901
Reference J Virol. 2002;76(18):9176-85.
Author Rao M, Bray M, Alving CR, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.