To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02212
Peptide Name BST-2/Tetherin
Sequence DDIWK
Sequence Length 5
UniProt ID No entry found
Taxon ID None
Source HIV-1
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1,EBOV,MV
Assay Antiviral Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not found
Mechanism BST-2, or Tetherin, restricts the release of Ebola virus-like particles (VLPs) from infected cells by tethering the budding virions to the cell membrane, thereby inhibiting their release. This restriction is similar to BST-2's activity against other enveloped viruses like HIV-1. However, Ebola glycoprotein (GP) has evolved mechanisms to counteract BST-2, enabling efficient release of Ebola VLPs. The specific molecular mechanisms by which Ebola GP antagonizes BST-2 are still under investigation, but it likely involves disrupting the interaction between BST-2 and virions, potentially by interfering with BST-2 ectodomain self-interaction.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C31H45N7O10
Absent amino acids ARNCQEGHLMFPSTYVOU
Common amino acids D
Mass 675.74
Pl 4.21
Basic residues 1
Acidic residues 2
Hydrophobic residues 2
Net charge -1
Boman Index 3.14
Hydrophobicity -1.46
Aliphatic Index 78
Half Life
Extinction Coefficient cystines 8800
Absorbance 280nm 8.139
Polar residues 0
Literature Information
Literature 1
Title Antiviral activity of the interferon-induced cellular protein BST-2/tetherin
Pubmed ID 19929170
Reference AIDS research and human retroviruses, 25(12), 1197–1210
Author Tokarev A, Skasko M, Fitzpatrick K, et al
Literature 2
Title Broad-Spectrum Inhibition of Retroviral and Filoviral Particle Release by Tetherin
Pubmed ID 19036818
Reference Journal of virology, 83(4), 1837–1844.
Author Jouvenet, N., Neil, S. J., Zhadina, M., Zang, T., Kratovac, Z., Lee, Y., McNatt, M., Hatziioannou, T., & Bieniasz, P. D. (2009).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.