DRAVP ID  DRAVPe02220

Peptide Name   RVFV-6

Sequence  WNFFDWFSGLMSWFGGPLK

Sequence Length  19

UniProt ID  P03518  P21403 

Taxon ID  11588 

Source  Rift Valley fever virus (RVFV) Gc stem region

Validation   Not experimentally validated

Gene Name/ID  GP

GenBank  Not Available

Amino Acid position  1140-1158

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  EBOV

Assay  Virus inhibition assays

Activity 

• [Ref:24069485]EBOV:IC50=50µM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref:24069485] Very very less toxic (MTT toxicity assays on Vero E6 cells assessed the toxicity of RVFV-6, revealing a reduction in cell viability at peptide concentrations up to 50 microM, suggesting

Binding Target  DII domain of the E protein (RVFV-6 interact with a specific region of the Ebola virus (EBOV) during

Mechanism  RVFV-6, a peptide derived from the RVFV Gc stem region, exhibits potent inhibition of Ebola virus (EBOV), achieving nearly 100% reduction in plaques at a 50 microM concentration. Despite not interfering with EBOV binding to cells, RVFV-6 effectively inhibits EBOV infectivity, suggesting its potential as an antiviral therapy against EBOV and related viruses.

PDB ID  4HJ1  4HJC  6EGT  6F9B 

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   A fusion-inhibiting peptide against Rift Valley fever virus inhibits multiple, diverse viruses

Pubmed ID   24069485

Reference   PLoS Negl Trop Dis. 2013;7(9):e2430.

Author   Koehler JW, Smith JM, Ripoll DR, et al.

DOI   10.1371/journal.pntd.0002430