To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02228
Peptide Name Peptide P
Sequence PGEKGPSGEAGTAGPPGTPGPQGL
Sequence Length 38
UniProt ID No entry found
Taxon ID None
Source cod skin hydrolysates
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism H1N1
Assay Cytopathic Effect Reduction
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Neuraminidase protein
Mechanism This compound showed a NA inhibitory activity with Ki of 0.29 mM, and it was demonstrated to directly bind to free enzymes. The cytopathic effect reduction assay showed that the peptide P protected MDCK cells from viral infection and reduced viral production in a dose-dependent manner with an EC50 value of 471 ± 12 μg/mL against PR8 (H1N1)
Structure Information
PDB ID Not Available
Linear/Cyclic Linear
N-terminal Modification Not included yet
C-terminal Modification Not included yet
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C90H142N26O33
Absent amino acids RNDCHIMFWYVOU
Common amino acids G
Mass 2116.27
Pl 4.53
Basic residues 1
Acidic residues 2
Hydrophobic residues 3
Net charge -1
Boman Index 0.71
Hydrophobicity -0.917
Aliphatic Index 24.58
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 14
Literature Information
Literature 1
Title A Novel Natural Influenza A H1N1 Virus Neuraminidase Inhibitory Peptide Derived from Cod Skin Hydrolysates and Its Antiviral Mechanism. Mar.
Pubmed ID 30308963
Reference Drugs. 2018;16:377. doi: 10.3390/md16100377.
Author Li J., Chen Y., Yuan N., Zeng M., Zhao Y., Yu R., Liu Z., Wu H., Dong S.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.