To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02229
Peptide Name IntPep
Sequence ELVDPVVAAGAVVTSSGIVFFS
Sequence Length 22
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism Influenza A H1N1
Assay Structural studies
Activity
Hemolytic Activity
Cytotoxicity
Binding Target Neuraminidase protein
Mechanism IntPep peptides were able to interact with the TM2 domain (region 316–333) of human NEU1 and disrupt its dimerization with consequent losses in sialidase activity. Furthermore, these IntPeps inhibit membrane sialidase activity triggered by elastin-derived peptides in macrophages, which are highly dependent on NEU1 .
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Not included yet
C-terminal Modification Not included yet
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C100H158N22O31
Absent amino acids RNCQHKMWYOU
Common amino acids V
Mass 2164.48
Pl 3.67
Basic residues 0
Acidic residues 2
Hydrophobic residues 13
Net charge -2
Boman Index -0.86
Hydrophobicity 1.455
Aliphatic Index 128.18
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Literature Information
Literature 1
Title Transmembrane Peptides as a New Strategy to Inhibit Neuraminidase-1 Activation
Pubmed ID 33392200
Reference Frontiers in cell and developmental biology, 8, 611121.
Author Albrecht, C., Kuznetsov, A. S., Appert-Collin, A., Dhaideh, Z., Callewaert, M., Bershatsky, Y. V., Urban, A. S., Bocharov, E. V., Bagnard, D., Baud, S., Blaise, S., Romier-Crouzet, B., Efremov, R. G., Dauchez, M., Duca, L., Gueroult, M., Maurice, P., & Bennasroune, A. (2020).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.