To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02231
Peptide Name HA-FP-1
Sequence GLFGAIAGFIKNGWKGMIKG
Sequence Length 20
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism Influenza A H1N1/A/Puerto Rico/8/34 (H1N1)
Assay Cytopathic Effect inhibition
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Hemagglutinin protein
Mechanism interfering with the fusogenic activity of HA. As revealed by fusion and hemolysis inhibition assays, these peptides specifically blocked the entry of IAV into host cells via the interaction of the pFPs and the HA2 subunit,most likely due to interactions between the N-terminal portion of HA2. The positively charged lysine residues of pFPs strongly interact with glutamic acid or aspartic acid, negatively charged, of the HA2 subunit via ionic contacts and hydrogen bonds
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Not included yet
C-terminal Modification Not included yet
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C98H153N25O22S1
Absent amino acids RDCQEHPSTYVOU
Common amino acids G
Mass 2065.51
Pl 10.03
Basic residues 3
Acidic residues 0
Hydrophobic residues 10
Net charge 3
Boman Index -0.81
Hydrophobicity 0.495
Aliphatic Index 88
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 2.663
Polar residues 1
Literature Information
Literature 1
Title New influenza A Virus Entry Inhibitors Derived from the Viral Fusion Peptides
Pubmed ID 26382764
Reference PloS one, 10(9), e0138426.
Author Wu, W., Lin, D., Shen, X., Li, F., Fang, Y., Li, K., Xun, T., Yang, G., Yang, J., Liu, S., & He, J. (2015).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.