To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02235
Peptide Name FP4
Sequence RRKKWLVFFVIFYFFR
Sequence Length 16
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism Influenza A H1N1
Assay Plaque reduction
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Hemagglutinin protein
Mechanism The mechanism of action was demonstrated to be the interference with the viral attachment via contact with HA, as demonstrated by ELISA assay, but they do not block hemagglutination produced by the virus, so they do not interact on the receptor binding site. Moreover, the compounds were tested on Balb/c mice infected with a lethal dose of A/WSN/33 virus, showing an ability to reduce the viral titer by 2–4 log units
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Not included yet
C-terminal Modification Not included yet
Other Modification Not included yet
Stereochemistry L
Physicochemical Information
Formula C117H166N28O18
Absent amino acids ANDCEQGHMPSTOU
Common amino acids F
Mass 2252.78
Pl 11.73
Basic residues 5
Acidic residues 0
Hydrophobic residues 10
Net charge 5
Boman Index 1.3
Hydrophobicity 0.45
Aliphatic Index 85
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 3.103
Polar residues 1
Literature Information
Literature 1
Title A novel family of peptides with potent activity against influenza A viruses
Pubmed ID 22258859
Reference The Journal of general virology, 93(Pt 5), 980–986.
Author Nicol, M. Q., Ligertwood, Y., Bacon, M. N., Dutia, B. M., & Nash, A. A. (2012).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.