To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02236
Peptide Name LEDGF/p75 (355-377)
Sequence IHAEIKNSLKIDNLDVNRCIEAL
Sequence Length 23
UniProt ID O75475
Taxon ID 9606
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID PSIP1
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1
Assay Not Available
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Integrase
Mechanism The LEDGF/p75 peptide modestly inhibited IN catalysis and was dependent on IN–DNA assembly. The peptide was also effective at disrupting LEDGF/p75–IN complex formation.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C113H193N33O36S
Absent amino acids FGMPQTWY
Common amino acids I
Mass 2622.03
Pl 5.48
Basic residues 4
Acidic residues 4
Hydrophobic residues 10
Net charge 0
Boman Index -41.68
Hydrophobicity -0.048
Aliphatic Index 140
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Literature Information
Literature 1
Title Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis
Pubmed ID 18331842
Reference FEBS Lett. 2008 Apr 30;582(10):1425-30.
Author Al-Mawsawi LQ, Christ F, Dayam R, Debyser Z, Neamati N.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.