General Information


DRAVP ID  DRAVPe02238

Peptide Name   C18-s2(1–5)

Sequence  ARLPR

Sequence Length  5

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  Influenza A H1N1/A/Puerto Rico/8 (H1N1)

Assay  Plaque reduction

Activity 

  • [Ref:20476787]IAV:IC50=1.9μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Binding the head of HA (protein present at the out membrane of the virus)

Mechanism  Not included yet



Structure Information


PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  C17H35CO

Stereochemistry  L



Physicochemical Information


Formula  C26H49N11O6

Absent amino acids  NDCQEGHIKMFSTWYVOU

Common amino acids  R

Mass  611.75

Pl  12

Basic residues  2

Acidic residues  0

Hydrophobic residues  2

Net charge  2

Boman Index  4.62

Hydrophobicity  -1

Aliphatic Index  98

Half Life 

  •     Mammalian:4.4 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0



Literature Information


Literature 1

Title   Sialic acid-mimic peptides as hemagglutinin inhibitors for anti-influenza therapy

Pubmed ID   20476787

Reference   Journal of medicinal chemistry, 53(11), 4441–4449.

Author   Matsubara, T., Onishi, A., Saito, T., Shimada, A., Inoue, H., Taki, T., Nagata, K., Okahata, Y., & Sato, T. (2010).

DOI   10.1021/jm1002183