To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02239
Peptide Name PVF-tet
Sequence MARRPVNHAUMARRPVNHAUMARRPVNHAUMARRPVNHAU
Sequence Length 40
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism Influenza A H1N1/A/Puerto Rico/8 (H1N1)
Assay Infection inhibition
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Head of HA
Mechanism This compound did not block viral entry into the cell as expected because of its binding to HA and did not act on the fusion process or in the HI assay. In fact, PVF-tet does not interact with H1 and H2, but likely does with the H0 of newly synthesized viral particles. PVF-tet is a cell-penetrating peptide, and its addition to the infected cell causes the amassment of HA in a vacuole-like structures named amphisomes
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Not included yet
C-terminal Modification Not included yet
Other Modification 4-3Lys
Stereochemistry L
Physicochemical Information
Formula C55H88N20O13S1Se1
Absent amino acids DCQEGILKSTWYO
Common amino acids AR
Mass 1348.45
Pl 12
Basic residues 2
Acidic residues 0
Hydrophobic residues 2
Net charge 2
Boman Index 4.87
Hydrophobicity -0.436
Aliphatic Index 44.5
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Literature Information
Literature 1
Title The inducible amphisome isolates viral hemagglutinin and defends against influenza A virus infection
Pubmed ID 31919357
Reference Nature communications, 11(1), 162.
Author Omi, J., Watanabe-Takahashi, M., Igai, K., Shimizu, E., Tseng, C. Y., Miyasaka, T., Waku, T., Hama, S., Nakanishi, R., Goto, Y., Nishino, Y., Miyazawa, A., Natori, Y., Yamashita, M., & Nishikawa, K. (2020)
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.