To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02240
Peptide Name iHA-100
Sequence WTGDFFSSHYTVPRC
Sequence Length 15
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism Influenza A H1N1/H5-HA
Assay Surface Plasmon Resonance
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Head of HA
Mechanism Escape mutant isolation demonstrated its binding at the stalk region of HA, confirmed by the stabilization effect its binding produces on HA trypsin degradation, but interaction on the globular head was not excluded. The macrocycle peptide was tested in vivo on mice infected with lethal H5N1 IAV. iHA-100 rescued 40% of mice and showed better efficacy when administered in the early or late phases of infection.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Not included yet
C-terminal Modification Not included yet
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C83H111N21O23S1
Absent amino acids ANQEILKMOU
Common amino acids FST
Mass 1802.98
Pl 6.73
Basic residues 1
Acidic residues 1
Hydrophobic residues 5
Net charge 0
Boman Index 1.72
Hydrophobicity -0.407
Aliphatic Index 19.33
Half Life
Extinction Coefficient cystines 6990
Absorbance 280nm 3.877
Polar residues 5
Literature Information
Literature 1
Title Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
Pubmed ID 33976181
Reference Nature communications, 12(1), 2654.
Author Saito, M., Itoh, Y., Yasui, F., Munakata, T., Yamane, D., Ozawa, M., Ito, R., Katoh, T., Ishigaki, H., Nakayama, M., Shichinohe, S., Yamaji, K., Yamamoto, N., Ikejiri, A., Honda, T., Sanada, T., Sakoda, Y., Kida, H., Le, T. Q. M., Kawaoka, Y., … Kohara, M. (2021).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.