DRAVP ID  DRAVPe02241

Peptide Name   P2

Sequence  FAPRWR

Sequence Length  6

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  Influenza A H9N1/A/chicken/Tunisia/12/2010 (H9N2)

Assay  In ovo antiviral activity

Activity 

• [Ref:35306102]IAV:IC50=620μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref:35306102]two peptides did not show toxicity on eggs and chicken lungs.

Binding Target  Head of HA

Mechanism  Molecular docking calculations, carried out to depict the interaction between active peptides and hemagglutinin, indicated that P1 and P2 peptides bind different regions of the HA globular head: P1 occupies the RBS, while P2 occupies a site close to the RBS and interacts with the 220-loop 

PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Not included yet

C-terminal Modification  Not included yet

Other Modification  None

Stereochemistry  L

Literature 1

Title   Inhibition of avian influenza virus H9N2 infection by antiviral hexapeptides that target viral attachment to epithelial cells

Pubmed ID   35306102

Reference   Virus research, 313, 198745.

Author   Arbi, M., Larbi, I., Nsiri, J., Behi, I. E., Rejeb, A., Miled, K., Ghram, A., & Houimel, M. (2022). 

DOI   10.1016/j.virusres.2022.198745