To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02242
Peptide Name P1
Sequence LSRMPK
Sequence Length 6
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism Influenza A H1N1/A/chicken/Tunisia/12/2010 (H9N2)
Assay In ovo antiviral activity
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Head of HA
Mechanism Molecular docking calculations, carried out to depict the interaction between active peptides and hemagglutinin, indicated that P1 and P2 peptides bind different regions of the HA globular head: P1 occupies the RBS, while P2 occupies a site close to the RBS and interacts with the 220-loop
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Not included yet
C-terminal Modification Not included yet
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C31H58N10O8S1
Absent amino acids ANDQEHIFTWYVOU
Common amino acids RLKMPS
Mass 730.92
Pl 11
Basic residues 2
Acidic residues 0
Hydrophobic residues 2
Net charge 2
Boman Index 2.76
Hydrophobicity -0.85
Aliphatic Index 65
Half Life
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Literature Information
Literature 1
Title Inhibition of avian influenza virus H9N2 infection by antiviral hexapeptides that target viral attachment to epithelial cells
Pubmed ID 35306102
Reference Virus research, 313, 198745.
Author Arbi, M., Larbi, I., Nsiri, J., Behi, I. E., Rejeb, A., Miled, K., Ghram, A., & Houimel, M. (2022).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.