General Information


DRAVP ID  DRAVPe02245

Peptide Name   PeB

Sequence  ARDFYDYDVFYYAMD

Sequence Length  15

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  Influenza A H3N2/A/Aichi/2/68 X31 (H3N2)

Assay  Infection inhibition

Activity 

  • [Ref:27415624]IAV:IC50=32 ± 5μM

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref:27415624]Neglible cytotoxicity

Binding Target  Head of HA

Mechanism  Not included yet



Structure Information


PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Not included yet

C-terminal Modification  Not included yet

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C92H116N18O28S1

Absent amino acids  NCQEGHILKPSTWVOU

Common amino acids  D

Mass  1954.1

Pl  3.77

Basic residues  1

Acidic residues  4

Hydrophobic residues  6

Net charge  -3

Boman Index  2.29

Hydrophobicity  -0.506

Aliphatic Index  32.67

Half Life 

  •     Mammalian:4.4 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  5960

Absorbance 280nm  3.05

Polar residues  4



Literature Information


Literature 1

Title   Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding

Pubmed ID   27415624

Reference   PloS one, 11(7), e0159074.

Author   Memczak, H., Lauster, D., Kar, P., Di Lella, S., Volkmer, R., Knecht, V., Herrmann, A., Ehrentreich-Förster, E., Bier, F. F., & Stöcklein, W. F. (2016).

DOI    10.1371/journal.pone.0159074