To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02247
Peptide Name p28
Sequence LSTAADMQGVVTDGMASGLDKDYLKPDD
Sequence Length 28
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism Influenza A H1N1
Assay Docking studies
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target PB1 (Basic polymerase 1 )
Mechanism Docking studies showed that the p28 region forms strong and stable interactions with the C-terminus of PB1 (C-PB1) and other proteins of H1N1 IAV
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Not included yet
C-terminal Modification Not included yet
Other Modification Not included yet
Stereochemistry L
Physicochemical Information
Formula C122H197N31O47S2
Absent amino acids RNCEHIFWOU
Common amino acids D
Mass 2914.21
Pl 3.85
Basic residues 2
Acidic residues 6
Hydrophobic residues 10
Net charge -4
Boman Index 1.61
Hydrophobicity -0.371
Aliphatic Index 73.21
Half Life
Extinction Coefficient cystines 1490
Absorbance 280nm 0.511
Polar residues 6
Literature Information
Literature 1
Title Therapeutic p28 peptide targets essential H1N1 influenza virus proteins: insights from docking and molecular dynamics simulations
Pubmed ID 33575983
Reference Molecular diversity, 25(3), 1929–1943.
Author Sasidharan, S., Gosu, V., Shin, D., Nath, S., Tripathi, T., & Saudagar, P. (2021).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.