To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02248
Peptide Name PB1-11
Sequence DYNPYLLFLK
Sequence Length 10
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism Influenza A H1N1
Assay AlphaScreen
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target PB1 (Basic polymerase 1 )
Mechanism The PB1-0 peptide has given excellent results in blocking the PA-PB1 interaction, in particular in the C-terminal domain of the PR8 (H1N1). The same results were confirmed by surface plasmon resonance (SPR) experiments. PB1-10 was obtained with the elimination of some amino acids from the N-terminus and C-terminus. With the addition of two substituents, the authors reached PB1-11, which proved to be the most active of all
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Not included yet
C-terminal Modification Not included yet
Other Modification Not included yet
Stereochemistry L
Physicochemical Information
Formula C64H92N12O16
Absent amino acids ARCQEGHIMSTWVOU
Common amino acids L
Mass 1285.51
Pl 5.83
Basic residues 1
Acidic residues 1
Hydrophobic residues 4
Net charge 0
Boman Index 0.34
Hydrophobicity -0.09
Aliphatic Index 117
Half Life
Extinction Coefficient cystines 2980
Absorbance 280nm 2.318
Polar residues 3
Literature Information
Literature 1
Title structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor
Pubmed ID 33166574
Reference Antiviral research, 185, 104971.
Author Hejdánek, J., Radilová, K., Pachl, P., Hodek, J., Machara, A., Weber, J., Řezáčová, P., Konvalinka, J., & Kožíšek, M. (2021).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.