General Information


DRAVP ID  DRAVPe02249

Peptide Name   FluAPep 1

Sequence  SRARIDARI

Sequence Length  9

UniProt ID  No entry found

Taxon ID  None

Source  Synthetic construct

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  Not Available

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  Influenza A H1N1

Assay  Docking studies

Activity 

  • [Ref:30597438]IAV:binding affinity (score = −246.155)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

  • [Ref:30597438]ToxinPred analysis confirmed that designed peptides were non-toxic.

Binding Target  PB1 (Basic polymerase 1 )

Mechanism  Not Available



Structure Information


PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C43H80N18O13

Absent amino acids  NCQEGHLKMFPTWYVOU

Common amino acids  R

Mass  1057.22

Pl  11.7

Basic residues  3

Acidic residues  1

Hydrophobic residues  4

Net charge  -2

Boman Index  4.82

Hydrophobicity  -0.578

Aliphatic Index  108.89

Half Life 

  •     Mammalian:1.9 hours
  •     Yeast:>20 hours
  •     E.coli:>10 hours

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1



Literature Information


Literature 1

Title   In silico structure-based design of enhanced peptide inhibitors targeting RNA polymerase PAN-PB1Cinteraction

Pubmed ID   30597438

Reference   Computational biology and chemistry, 78, 273–281.

Author   Arivajiagane, A., Ravi Varadharajulu, N., Seerangan, K., & Rattinam, R. (2019).

DOI    10.1016/j.compbiolchem.2018.12.009