To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02251
Peptide Name Siamycin I (Bacteriocin)
Sequence CLGVGSCNDFAGCGYAVVCFW
Sequence Length 21
UniProt ID No entry found
Taxon ID None
Source Streptomyces strain AA6532
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1
Assay CPEb (XTT)
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Not Found
Mechanism Not Available
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification Two disulfide bonds linking Cys-1 with Cys-13and Cys-7 with Cys-19, as well as an amide bond joining the side chain of Asp-9 to the N-terminus Cys-1. Amino acid anal- ysis revealed that both compounds contained the same residues with the exception that one of two valines in saimycin I is replaced by isoleucine in siamycin II.
Stereochemistry L
Physicochemical Information
Formula C96H135N23O27S4
Absent amino acids EHIKMPQRT
Common amino acids CG
Mass 2171.51
Pl 3.8
Basic residues 0
Acidic residues 1
Hydrophobic residues 9
Net charge -1
Boman Index 1.893
Hydrophobicity 1.143
Aliphatic Index 69.52
Half Life
Extinction Coefficient cystines 7240
Absorbance 280nm 362
Polar residues 11
Literature Information
Literature 1
Title Siamycins I and II, new anti-HIV-1 peptides: II. Sequence analysis and structure determination of siamycin I;
Pubmed ID 8557614
Reference J Antibiot (Tokyo). 1995 Dec;48(12):1515-7;
Author Detlefsen DJ, Hill SE, Volk KJ, Klohr SE, Tsunakawa M, Furumai T, Lin PF, Nishio M, Kawano K, Oki T, et al;
DOI 10.7164/antibiotics.48.1515;
Literature 2
Title Siamycins I and II, new anti-HIV peptides: I. Fermentation, isolation, biological activity and initial characterization
Pubmed ID 7797448
Reference The Journal of antibiotics, 48(5), 433–434.
Author Tsunakawa, M., Hu, S. L., Hoshino, Y., Detlefson, D. J., Hill, S. E., Furumai, T., White, R. J., Nishio, M., Kawano, K., & Yamamoto, S. (1995).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.