To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02257
Peptide Name H-HR2-S
Sequence TSDVAAATNADLRTALARADHQKTLFWL
Sequence Length 28
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HSV-1
Assay Virus entry assays.
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity
Binding Target Fusion machinery
Mechanism The peptides derived from the heptad repeat (HR) regions of HSV-1 glycoproteins (gH and gB) inhibit the virus entry process by interfering with membrane fusion.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C134H214N40O42
Absent amino acids CEGIMPYOU
Common amino acids A
Mass 3057.42
Pl 6.42
Basic residues 3
Acidic residues 3
Hydrophobic residues 14
Net charge 0
Boman Index 1.79
Hydrophobicity -0.118
Aliphatic Index 91.07
Half Life
Extinction Coefficient cystines 5500
Absorbance 280nm 1.799
Polar residues 7
Literature Information
Literature 1
Title Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and B.
Pubmed ID 16603508
Reference The Journal of general virology, 87(Pt 5), 1085–1097.
Author Galdiero, S., Vitiello, M., D'Isanto, M., Falanga, A., Collins, C., Raieta, K., Pedone, C., Browne, H., & Galdiero, M. (2006).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.