To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02282
Peptide Name Rabbit neutrophil defensin 3a
Sequence GICACRRRFCPNSERFSGYCRVNGARYVRCCSRR
Sequence Length 34
UniProt ID P07469
Taxon ID 9986
Source Rabbit, O. cuniculus
Validation Experimentally Validated
Origin Information
Gene Name/ID Corticostatin 1(protein)
GenBank
Amino Acid position 60-93
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism IAV
Assay Antiviral Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not Found
Mechanism Not Available
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification Three disulfide bridges
Stereochemistry L
Physicochemical Information
Formula C163H265N63O44S6
Absent amino acids DHKLMOQTUW
Common amino acids R
Mass 4003.65
Pl 10.2
Basic residues 9
Acidic residues 1
Hydrophobic residues 7
Net charge 8
Boman Index 3.87
Hydrophobicity -0.638
Aliphatic Index 76.04
Half Life
Extinction Coefficient cystines 3355
Absorbance 280nm 0.838
Polar residues 23
Literature Information
Literature 1
Title NP-1, a rabbit alpha defensin, prevents the entry and intercellular spread of herpes simplex virus type 2.
Pubmed ID 12543649
Reference Antimicrobial agents and chemotherapy, 47(2), 494–500
Author Sinha, S., Cheshenko, N., Lehrer, R. I., & Herold, B. C. (2003).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.