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General Information
DRAVP ID DRAVPe02283
Peptide Name MCP-2
Sequence VVCACRRALCLPLERRAGFCRIRGRIHPLCCRR
Sequence Length 33
UniProt ID P01377
Taxon ID 9986
Source Macrophage, lung, Rabbit,Oryctolagus cuniculus
Validation Experimentally Validated
Origin Information
Gene Name/ID Defensin alpha 4(protein)
GenBank AAA31390.1
Amino Acid position 63-95
Domain Accession ID Not Available
Nucleotide sequence ID M28884
Molecular Type mRNA
Chromosomal Position Scaffold GL018713: 117,470-184,536 forward strand.
Activity Information
Target Organism HSV-1
Assay Antiviral Assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not Found
Mechanism MCP-1 and MCP-2 can directly neutralize several viruses in vitro and that HSV-1 strain Maclntyre and vesicular stomatitis virus strain Indiana are particularly susceptible to their action.
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C161H282N62O36S6
Absent amino acids DKMNOQSTUWY
Common amino acids R
Mass 3854.76
Pl 11.12
Basic residues 9
Acidic residues 1
Hydrophobic residues 12
Net charge 8
Boman Index 2.73
Hydrophobicity 0.139
Aliphatic Index 97.58
Half Life
Extinction Coefficient cystines 375
Absorbance 280nm 0.097
Polar residues 17
Literature Information
Literature 1
Title Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes
Pubmed ID 2985808
Reference Journal of virology, 54(2), 467–472.
Author Lehrer, R. I., Daher, K., Ganz, T., & Selsted, M. E. (1985).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.