DRAVP ID  DRAVPe02285

Peptide Name   Mundticin(CRL35)

Sequence  KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWKS

Sequence Length  43

UniProt ID  B6DSR2 

Taxon ID  1352 

Source  Enterococcus mundtii NFRI 7397

Validation   Experimentally Validated

Gene Name/ID  mundKS

GenBank  Not Available

Amino Acid position  16-58

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HSV

Assay  Antiviral Assay

Activity 

• [Ref:10493605]HSV-1 (F):Vero cells:Inhibition = 97.0%, BHK-21 cells:Inhibition = 99.2%.HSV-2 (G):Vero cells:Inhibition = 98.8%, BHK-21 cells:Inhibition = 98.8%.HSV-1 (B2006):Vero cells:Inhibition = 92.4%, BHK-21 cells:Inhibition = 96.7%.HSV-1 (F): EC50 = 11 µg/ml,HSV-1 (B2006): EC50 = 53 µg/ml,HSV-1 (KOS): EC50 = 60 µg/ml for Enterocin,HSV-1 (Field): EC50 = 76 µg/ml for Enterocin,HSV-2 (G): EC50 = 15 µg/ml for Enterocin

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref:10493605]CC50 of CRL35:HSV-1 (F): 1363.64 µg/ml,HSV-1 (B2006): 283.02 µg/ml,HSV-1 (KOS): 250.00 µg/ml,HSV-1 (Field isolate): 197.37 µg/ml,HSV-2 (G): 1000.00 µg/ml.

Binding Target  Not Found

Mechanism  Enterocin CRL35 exerted a significant inhibitory effect in vitro on the replication of several HSV strains.

PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Antiviral activity of enterocin CRL35 against herpesviruses

Pubmed ID   10493605

Reference   International journal of antimicrobial agents, 12(4), 293–299.

Author   Wachsman, M. B., Farías, M. E., Takeda, E., Sesma, F., de Ruiz Holgado, A. P., de Torres, R. A., & Coto, C. E. (1999).

DOI   10.1016/s0924-8579(99)00078-3