To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02292
Peptide Name Protegrin 2
Sequence RGGRLCYCRRRFCICV
Sequence Length 16
UniProt ID P32195
Taxon ID 9823
Source Leukocytes; porcine neutrophil, pig,S. scrofa
Validation Experimentally Validated
Origin Information
Gene Name/ID NPG2
GenBank Not Available
Amino Acid position 131-146
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HSV-1,HSV-2.SARS-CoV-2
Assay BRET-based assay
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not Found
Mechanism Not Available
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification Disulfide bridge formation was performed on crude peptides.
Stereochemistry L
Physicochemical Information
Formula C81H137N31O18S4
Absent amino acids ADEHKMNOPQSTUW
Common amino acids R
Mass 1961.42
Pl 9.88
Basic residues 5
Acidic residues 0
Hydrophobic residues 4
Net charge 5
Boman Index 3.18
Hydrophobicity 0.044
Aliphatic Index 66.88
Half Life
Extinction Coefficient cystines 1740
Absorbance 280nm 0.887
Polar residues 10
Literature Information
Literature 1
Title Synthesis of protegrin-related peptides and their antibacterial and anti-human immunodeficiency virus activity
Pubmed ID 8647100
Reference Chem Pharm Bull (Tokyo). 1995 May;43(5):853-858
Author Tamamura H, Murakami T, Horiuchi S, Sugihara K, Otaka A, Takada W, Ibuka T, Waki M, Yamamoto N, Fujii N
DOI 10.1111/j.1432-1033.1996.0575p.x
Literature 2
Title Protegrin-2, a potential inhibitor for targeting SARS-CoV-2 main protease Mpro
Pubmed ID 37576748
Reference Computational and structural biotechnology journal, 21, 3665–3671.
Author Jan, Z., Geethakumari, A. M., Biswas, K. H., & Jithesh, P. V. (2023)
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.