To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02293
Peptide Name eVpeL1
Sequence YYSSRWNHGHFTPCS
Sequence Length 15
UniProt ID No entry found
Taxon ID None
Source Synthetic construct
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay inhibitory Assay
Activity Not Available
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target VP24
Mechanism Exact MoA not known (eVpeL1, a macrocyclic peptide belonging to the GL1 group from the LY-library, was found to be a poor binder to the immobilized eVP24 compared to other peptides like eVpeD1 and eVpeD2).
Structure Information
PDB ID None
Linear/Cyclic Linear
N-terminal Modification Acetylation
C-terminal Modification Amination
Other Modification In the peptide sequence, the N-terminus is acetylated, and the tyrosine residue at position 1 is in the D-configuration
Stereochemistry L
Physicochemical Information
Formula C83H108N24O23S1
Absent amino acids ADEIKLMOQUV
Common amino acids S
Mass 1841.98
Pl 8.21
Basic residues 1
Acidic residues 0
Hydrophobic residues 2
Net charge 1
Boman Index 2.42
Hydrophobicity -1.18
Aliphatic Index 0
Half Life
Extinction Coefficient cystines 8480
Absorbance 280nm 4.604
Polar residues 11
Literature Information
Literature 1
Title Macrocyclic peptide inhibitors for the protein-protein interaction of Zaire Ebola virus protein 24 and karyopherin alpha 5.
Pubmed ID 28574091
Reference Org Biomol Chem. 2017;15(24):5155-5160.
Author Song X, Lu LY, Passioura T, et al.
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.