To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.
General Information
DRAVP ID DRAVPe02297
Peptide Name Retrocyclin-3
Sequence RICRCICGRRICRCICGR
Sequence Length 18
UniProt ID No entry found
Taxon ID None
Source Derived from a silent gene (pre-stop)
Validation Experimentally Validated
Origin Information
Gene Name/ID Not Available
GenBank Not Available
Amino Acid position Not Available
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism HIV-1
Assay Luciferase Assay
Activity Not Available
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target Not Found
Mechanism It binds to gp120 and CD4, thereby inhibiting HIV entry.
Structure Information
PDB ID None
Linear/Cyclic Cyclic
N-terminal Modification Free
C-terminal Modification Free
Other Modification three intramolecular disulfide bonds
Stereochemistry L
Physicochemical Information
Formula C82H154N36O19S6
Absent amino acids ADEFHKLMNOPQSTUVWY
Common amino acids CR
Mass 2140.71
Pl 9.69
Basic residues 6
Acidic residues 0
Hydrophobic residues 4
Net charge 6
Boman Index 3.34
Hydrophobicity 0.289
Aliphatic Index 86.67
Half Life
Extinction Coefficient cystines 375
Absorbance 280nm 0.175
Polar residues 12
Literature Information
Literature 1
Title Activity of alpha- and theta-defensins against primary isolates of HIV-1
Pubmed ID 15210812
Reference Journal of immunology (Baltimore, Md. : 1950), 173(1), 515–520.
Author Wang, W., Owen, S. M., Rudolph, D. L., Cole, A. M., Hong, T., Waring, A. J., Lal, R. B., & Lehrer, R. I. (2004).
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.