DRAVP ID  DRAVPe02298

Peptide Name   Rondonin

Sequence  IIIQYEGHKH

Sequence Length  10

UniProt ID  B3EWP8 

Taxon ID  1211104 

Source  Haemolymph, Eurypelma californicum and Acanthoscurria gomesiana;

Validation   Experimentally Validated

Gene Name/ID  Rondonin(protein)

GenBank  Not Available

Amino Acid position  1 to 10

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  McV, IAV, EMCV

Assay  Antiviral Activity Assay

Activity 

• [Ref:34254458]McV: Rondonin inhibited ½ dilution of the virus (MDCK, titer 1/256); H1N1: Rondonin inhibited 1/64 dilution (Vero Cells); Rondonin (6 µg) inhibited viral mRNA completely at 7.5 ng.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity 

• [Ref:34254458]Not cytotoxic against mammalian cells

Binding Target  Not Found

Mechanism  the mechanism of action of this peptide probably involves internal components of the microorganisms. With these results of the RNA virus test, enveloped or not, we verified the protection of the cells, avoiding viral replication. At higher concentrations of rondonin, complete blocked of the DNA was observed, showing that the DNA was aggregated by rondonin

PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Rondonin: antimicrobial properties and mechanism of action

Pubmed ID   34254458

Reference   FEBS open bio, 11(9), 2541–2559.

Author   Riciluca, K. C. T., Oliveira, U. C., Mendonça, R. Z., Bozelli Junior, J. C., Schreier, S., & da Silva Junior, P. I. (2021).

DOI    10.1002/2211-5463.13253