General Information


DRAVP ID  DRAVPe02299

Peptide Name   SA-hepcidin2

Sequence  NPAGCRFCCGCCPNMIGCGVCCRF

Sequence Length  24

UniProt ID  A0A142LQX2 

Taxon ID  None

Source  Liver, spotted scat, Scatophagus argus

Validation   Experimentally Validated



Origin Information


Gene Name/ID  Hepcidin(protein)

GenBank  Not Available

Amino Acid position  65-88

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available



Activity Information


Target Organism  SCRV, MsReV

Assay  Antiviral Assay

Activity 

  • [ReF:26845697]SCRV:IC50: 50 μM,MsReV:Ic50=25 μM,SA-hepcidin2 showed a dose-dependent protective effect against SCRV and MsReV.CPE in GCF and EPC monolayers after co-treatment with SA-hepcidins (50 μM) and virus (0.1TCID50)

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not Found

Mechanism  direct effects on the virion and effects on the innate and adaptive immunity of target cells 



Structure Information


PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L



Physicochemical Information


Formula  C99H156N32O27S9

Absent amino acids  DEHKLOQSTUWY

Common amino acids  C

Mass  2515.07

Pl  8.23

Basic residues  2

Acidic residues  0

Hydrophobic residues  6

Net charge  2

Boman Index  0.41

Hydrophobicity  0.717

Aliphatic Index  32.5

Half Life 

  •     Mammalian:1.4hours
  •     Yeast:3min
  •     E.coli:>10hours

Extinction Coefficient cystines  500

Absorbance 280nm  0.199

Polar residues  12



Literature Information


Literature 1

Title   Two hepcidins from spotted scat (Scatophagus argus) possess antibacterial and antiviral functions in vitro

Pubmed ID   26845697

Reference   Fish & shellfish immunology, 50, 191–199.

Author   Gui, L., Zhang, P., Zhang, Q., & Zhang, J. (2016). 

DOI   10.1016/j.fsi.2016.01.038