DRAVP ID  DRAVPe02300

Peptide Name   Sesquin

Sequence  KTCENLADTY

Sequence Length  10

UniProt ID  P84868 

Taxon ID  138955 

Source  Seeds, Vigna sesquipedalis, ground beans.

Validation   Experimentally Validated

Gene Name/ID  Not Available

GenBank  Not Available

Amino Acid position  1 to 10

Domain Accession ID  Not Available

Nucleotide sequence ID  Not Available

Molecular Type  Not Available

Chromosomal Position  Not Available

Target Organism  HIV-1

Assay  HIV reverse transcriptase inhibitory activity Assay

Activity 

• [Ref:15949629]HIV-1:(% inhibition at 50 μM) = 35 ± 3%,(% inhibition at 100 μM) = 45 ± 5%,(% inhibition at 200 μM) = 61 ± 2%.

Hemolytic Activity  No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity  No cytotoxicity information found in the reference(s) presented

Binding Target  Not Found

Mechanism  it inhibits HIV-1 reverse transcriptase.

PDB ID  None

Predicted Structure Download 

Linear/Cyclic  Linear

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Stereochemistry  L

Literature 1

Title   Sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and HIV-1 reverse transcriptase

Pubmed ID   15949629

Reference    Peptides, 26(7), 1120–1126.

Author   Wong, J. H., & Ng, T. B. (2005). 

DOI   10.1016/j.peptides.2005.01.003