General Information

General Information

DRAVP ID DRAVPe02305

Peptide Name Temporin-PTa

Sequence FFGSVLKLIPKIL

Sequence Length 13

UniProt ID P0C8U2

Taxon ID 395594

Source Hylarana picturata, Asia

Validation Experimentally Validated

Origin Information

Gene Name/ID Temporin-Pta(protein)

GenBank Not Available

Amino Acid position 1 to 13

Domain Accession ID Not Available

Nucleotide sequence ID Not Available

Molecular Type Not Available

Chromosomal Position Not Available

Activity Information

Target Organism HIV-1

Assay Antiviral Activity Assay

Activity

[Ref:30669255]HIV-1:EC50=0.63 uM,Tb inhibited viral replication at 5 μM,HSV-1:EC50=40 μM

Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry

Cytotoxicity

[Ref:30669255]Tb was tested at concentrations ranging from 5 (7 µg/mL) to 60 µM (84 µg/mL) [21]. Significant cytotoxicity was only observed at the highest concentration used (60 μM) with a cell viabil

Binding Target Membrane

Mechanism Inhibit Viral replication

Structure Information

PDB ID None

Predicted Structure Download

Linear/Cyclic Linear

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Stereochemistry L

Physicochemical Information

Formula C75H123N15O15

Absent amino acids ACDEHMNOQRTUWY

Common amino acids L

Mass 1474.89

Pl 10

Basic residues 2

Acidic residues 0

Hydrophobic residues 8

Net charge 2

Boman Index -1.61

Hydrophobicity 1.508

Aliphatic Index 172.31

Half Life

Mammalian:1.1hours
Yeast:3min
E.coli:2min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Literature Information

Literature 1

Title Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K³]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1

Pubmed ID 30669255

Reference Viruses, 11(1), 77.

Author Roy, M., Lebeau, L., Chessa, C., Damour, A., Ladram, A., Oury, B., Boutolleau, D., Bodet, C., & Lévêque, N. (2019).

DOI 10.3390/v11010077