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General Information
DRAVP ID DRAVPe02313
Peptide Name RVFV-10
Sequence SGSWNFFDWFSGLMSWFGGPL
Sequence Length 21
Taxon ID 11588
Source Rift Valley fever virus (RVFV) Gc stem region
Validation Experimentally Validated
Origin Information
Gene Name/ID GP
GenBank Not Available
Amino Acid position 1137-1157
Domain Accession ID Not Available
Nucleotide sequence ID Not Available
Molecular Type Not Available
Chromosomal Position Not Available
Activity Information
Target Organism EBOV
Assay Not Available
Activity
Hemolytic Activity No hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity No cytotoxicity information found in the reference(s) presented
Binding Target DII domain of the E protein (RVFV-10 may interact with a specific region of the Ebola virus (EBOV) d
Mechanism RVFV-10, a fusion-inhibiting peptide derived from the RVFV Gc stem region, displayed inhibitory effects against Ebola virus (EBOV) in a plaque-reduction assay, albeit less effectively than RVFV-6. Despite demonstrating weaker inhibition compared to RVFV-6, RVFV-10's efficacy against EBOV prompted further evaluation, ultimately leading to the selection of RVFV-6 for subsequent studies due to its superior inhibitory activity.
Structure Information
PDB ID 6EGT
Linear/Cyclic Linear
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Stereochemistry L
Physicochemical Information
Formula C119H149N25O29S1
Absent amino acids ACEHIKOQRTUVY
Common amino acids FGS
Mass 2425.7
Pl 3.8
Basic residues 0
Acidic residues 1
Hydrophobic residues 10
Net charge -1
Boman Index -0.28
Hydrophobicity 0.219
Aliphatic Index 37.14
Half Life
Extinction Coefficient cystines 16500
Absorbance 280nm 6.802
Polar residues 6
Literature Information
Literature 1
Title A fusion-inhibiting peptide against Rift Valley fever virus inhibits multiple, diverse viruses
Pubmed ID 24069485
Reference PLoS Negl Trop Dis. 2013;7(9):e2430.
Author Koehler JW, Smith JM, Ripoll DR
To the extent possible under law, the person who associated CC0 with this work has waived all copyright and related or neighboring rights to this work.